Spray Polyurethane Foam (SPF) Poor controls and work practices during polyurethane foam spraying can lead to health effects from exposure to MDI (methylene diphenyl diisocyanate) and its pre-polymers. paper) 1. EFFECT OF OVEREXPOSURE -CHRONIC HAZARDS:Repeated or prolonged exposure may cause respiratory system damage. j�����rk�&~�P�{���:ߕ�Lc��v�t,|���[Հ�뤳R�{&w��U�3�ߏ������Y"��0��N���أ���~�*�����;��0� �&�x�j:h%����|�s�D�u�~@���s���y���+|�M���%)x�$�6���?R�H�l�ydC�^U�U��yy�XI����&4�+��«Ɛ��&�x)ga�`gWp4�+��I��B���IE1�f@�Ƈ{I�|�+�MnV�q�Q�a|ςk8@�gm� Environmental Protection Agency. The 3315 E. Division Street • Arlington, TX 76011 A -PMDI Safety Data Sheet Unusual Fire / Explosion Hazards A hazardous pressure buildup could result due to reaction with water producing CO Outterside. {�>~t0H:����B� 389 0 obj <>stream A source book and practical guide / edited by D.C. Allport, D.S. Methylenediphenyl diisocyanate–Safety measures. Decontaminate equipment and protective clothing prior to reuse. Spray Polyurethane Foam (SPF) Poor controls and work practices during polyurethane foam spraying can lead to health effects from exposure to MDI (methylene diphenyl diisocyanate) and its pre-polymers. Roofers and insulation workers can be exposed to MDI by breathing it in, through skin Methylenediphenyl diisocyanate–Safety measures. Methylene Diphenyl Diisocyanate (MDI) And Related Compounds . ��;� ��C%�2����8���7���,�����W� ���"+�R��֮H��Z]�Ԉq}m����^��'��o{"w4�e�K�XJ)��~E��Z�x]�XL{>��R Includes bibliographical references and index. 4,4'-Diphenylmethane diisocyanate, MDI, Methylene di-p-phenylene ester of isocyanic acid, Methylene bis(4-phenyl isocyanate) White to light-yellow, odorless flakes. National Center for Environmental Assessment, Office of Research and Development, Research Triangle Park, NC. Hazard statements: Causes skin irritation Causes eye irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction May cause cancer via inhalation of respirable dust May cause respiratory irritation May cause damage to organs through prolonged or repeated exposure May form combustible dust concentrations in air �b5 Hazardous Substances Data Bank (HSDB) MDI usually occurs as a mixture of several isomers and oligomers: one common mixture is approximately 30-40% diphenylmethane-4,4'-diisocyanate, 2.5-4.0% diphenylmethane-2,4'-diisocyanate, 0.1-0.2 % diphenylmethane-2,2'- diisocyanate, and … �>Zs/ջ���(eF��� Coughing with chest pain or tightness may also occur, frequently at night. Outterside. A source book and practical guide / edited by D.C. Allport, D.S. However, it, like the other isocyanates, is an allergen and sensitizer. Symptoms include eye and nose irritation, dry or sore throat, runny nose, shortness of breath, wheezing and laryngitis. 3. In contrast to bronchial asthma, alveolitis has been reported in isolated case 3. 2. Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. an APR is selected, the airborne diisocyanate concentration must be no greater than 10 times the TLV or PEL. endstream endobj 350 0 obj <>>>/Filter/Standard/Length 128/O(�9A����J\\�&�����=���5P�n�Ͽ2_)/P -1340/R 4/StmF/StdCF/StrF/StdCF/U(R.sNt�JG�cᗗv�� )/V 4>> endobj 351 0 obj <> endobj 352 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 353 0 obj <>stream Roofers and insulation workers can be exposed to MDI by breathing it in, through skin Includes bibliographical references and index. Methylenediphenyl diisocyanate ORAL LD50 RAT > 7,400 MG/KG INHALATION LC50-4H RAT 0.37 MG/L DERMAL LD50 RABBIT > 6,200.00 MG/KG This product is a mixture. endstream endobj startxref Hazard Recognition. p. cm. 6.U.S. Gilbert, and S.M. ISBN 0-471-95812-3 (alk. p. cm. Unless noted, the information below is based on components. Exposure to heated diisocyanate can be extremely dangerous. Implementing an Isocyanate Safety Plan for . %PDF-1.6 %���� According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may … It has a CASRN of 9016-87-9. Action Plan [RIN 2070-ZA15] I. Overview . This Action Plan addresses the use of methylene diphenyl diisocyanate (MDI) and related compounds (See Appendix 1) in products that may result in consumer and general population R�0�;�cMk������Z2�����9�7� �r�ɧC�z"xbAhhG���=��d-���F�Ш�hSb�#��V����t�.i^Y�!8 ��&��HL3�o�`��3�o�u�Kɭ�h�6u���C�4{��hl���h�t�4����L�%�����iAY�����>�D����6;f,b��l�(�{��+�ڭ��R��¥��-WMKd�|�n� The “polymeric” forms of MDI, which typically consist of 30-70 percent monomeric diphenylmethane diisocyanate and the balance in higher molecular weight fractions (CAS # 5873-54-1) may at times be generically referred to as MDI. �v�3�KW���u��L���*m�7eP����c�נ +�7�*�v1�� C���Y��O��471��W�u�� There was some suggestion of increased risk at the higher exposure level for lung cancer with a relative risk of 126 (95% CI=39-409) and respiratory diseases(95% CI=54-573). Handling MDI requires strict engineering controls and personal protective equipment. Implementing an Isocyanate Safety Plan for . It is used to make plastics. Its very low vapour pressure reduces its hazards during handling compared to the other major isocyanates (TDI, HDI).